I run Mobile 1 in everything I own, except, our 99LT. We were told with 48k miles, it was too risky to now change to synth. The oil removes the paraffin from the seals having used the dino oil, which then leads to the clutch going. It was not worth the risk for us to do so.
Were it not for the dry clutch, I would not hesitate to switch.
I had 35k on my Ford when I switched, and did so with the engine, trans, rear. It ran significantly better, shifted better and is much easier to start in cold Pa winters.
I decided to do so after using the synth in our snowblower. The first two years I could not start the blower without the electric starter. Once I switched to synth, I have not used the starter since.
I am sure it is the way to go!