Very low RPM will wear out crank and rod bearings faster than higher, especially if you routinely are at high throttle settings at low speed. That is commonly called "lugging" the engine. Lubrication of the bearings is based on the "hydrodynamic wedge" principle, where the oil being "sheared" between the bearing surfaces creats a wedge between the surfaces. At lower RPM this wedge is much shorter, beginning where the oil is introduced between them (at the oil hole in the crank, and somewhat at the edge of the bearing insert that is beveled). This can allow the bearing surfaces to touch, where at higher RPM the wedge is much longer, and the wedge creates higher pressure between the surfaces. As the crank rotates, the oil introduction hole moves around the bearing, and when it is approaching the non load side, the pressure created by the shearing action of the oil will not reach the other side of the bearing where it is really needed. There will usually be a microscopic film of oil there, hopefully keeping the bearings from touching, but this can be tenous. Best to keep the high pressure shear wedge as far around the bearing as you can to keep the bearings seperated as much as possible.
Low RPM engines, like V-Twins, normally have much larger crank journals, so that the surface speed of the bearing surfaces is still reasonably high at lower RPM. The crank journals on higher performance engines are typically much smaller so that the pearing surface speed at their normally higher RPM stays in a reasonable range at red-line. They do NOT like high power settings at low RPM.
If you want to expect the best life of the LT crank bearings, do not do high throttle at under 3,000-3,500 RPM! It is perfectly fine to loaf along on the highway at low RPM, but if you need to use high power, as to pass, DOWNSHIFT! You will pass much faster, and be doing the engine a big favor.
When accellerating at high throttle settings, keep the RPM high enough so that when you shift to the next higher gear it does not drop below 3,500. Better for the engine, and a heck of a lot more fun.
About the only time my LT ever saw below 3,000 RPM was on start from stopped. Never did that at high throttle, waited until the RPM was up a little before the "big twist". Even on the highway, I did not use 5th gear until I could do so at above 3,500. I would downshift at above 3,000.
When you have a basic understanding of mechanical engineering and engine design principles, you tend to drive/ride differently. Others do it because it is more fun.
